A checklist of Orchidaceae from Caquetá Colombia is presented here. We recorded 96 genera and 414 species, exceeding a previous inventory by 272 species. The checklist is conservative in the number of genera and species by including only taxa that were fully and reliably identified and that are either linked to a corresponding herbarium voucher, a living collection specimen, or a photo taken in the field and published at iNaturalist by one of the authors. The documented species diversity in the region could dramatically increase in the next few years with additional collecting efforts in the eastern slope of the Andes nested in Caquetá. About 9 % (414/4600) of all Orchidaceae species recorded for Colombia are reported for this area, showing the important role of Andean-Amazonian foothills and all other ecosystems of this region.