Kenneth Alibek‡, Luiza Niyazmetova§, Sean Farmer|, Terence Isakov¶Corresponding author: Kenneth Alibek ( kalibek@locusfs.com ) Corresponding author: Luiza Niyazmetova ( luiza.niyazmetova@icloud.com ) © Kenneth Alibek, Luiza Niyazmetova, Sean Farmer, Terence Isakov. This is an open access preprint distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Citation:
Alibek K, Niyazmetova L, Farmer S, Isakov T (2022) Infectious agents cause immune system dysregulation in children with autism spectrum disorder. ARPHA Preprints. https://doi.org/10.3897/arphapreprints.e97856 |  |
The most recent studies and publications demonstrate the enormous role of infectious agents and chronic inflammation not only in various comorbid conditions in autistic patients but also in the dysregulation of the immune system, which in turn leads to the accumulation of immunodeficiency states and to a worsening of the autistic phenotype. Therefore, the focus of this article is on how congenital and early postnatal infections found in children with autism spectrum disorders may trigger the chain of pathological events found in autism. We discuss how some infectious agents such as Toxoplasma gondii, measles, rubella, cytomegalovirus, Epstein-Barr virus, and herpes-simplex virus-1 and 2 are involved in the dysregulation of immunity and nervous system abnormalities. Furthermore, we want to provide recommendations for potential combined treatment methods for patients with autism with concomitant immune dysfunction.